Friday, February 20, 2009

Th17 story

increased IL-17 from fresh KO T cells

decreased IL-17 under in vitro Th17 differentiation conditions with low TGF-beta

higher TGF-beta or anti-IL-4 Ab restores defect

but what causes increased IL-17 in vivo?

under some conditions, increased IL-17 seen from KO T cells differentiated in vitro

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